The 2020-21 Iona Gaels men's basketball team represented Iona College in the 2020-21 NCAA Division 1 men's basketball season. The Gaels, led by first-year head coach Rick Pitino, played their home games at the Hynes Athletic Center as members of the Metro Atlantic Athletic Conference. In a season limited due to the ongoing pandemic, they finished the season 12-6, 6-3 in MAAC play to finish in a tie for ninth place. As the No. 9 seed in the MAAC Tournament, they defeated Quinnipiac, Siena, and Niagara to advance to the tournament championship game. They defeated Fairfield to win the tournament championship and earned the conference's automatic bid to the NCAA tournament. They received a No. 15 seed in the East region, and lost in the First round to No. 2 seed Alabama 55-68.

The Gaels marked the fifth team Pitino had taken to the NCAA Tournament, tying him with Lon Kruger and Tubby Smith, for the record for most teams taken to the tournament.

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